For forests to be sustainable, viable populations of rare plants should be maintained. Where habitat management alone cannot conserve species threatened by human activity, micropropagation may advance species recovery. Micropropagation protocols were developed for Pacific Northwest endemics; Hackelia venusta, Douglasia idahoensis, Astragalus species, and Cornus nuttallii. Microshoots and seed were multiplied and rooted on nutrient media containning minimal levels of cytokinin and auxin growth regulators to maintain stable gene expression in plantlets. Acclimatized plantlets were reintroduced to protected habitat or propagated for further environmental experiments. Micropropagation serves a useful offsite role in sustaining Pacific Northwest forests by maintaining viability of certain threatened rare plants.