We analyzed the biotic, abiotic, and human components interacting at the coastal zone of the Ojo de Liebre Lagoon, Baja California Sur, Mexico. Using geographic information systems, satellite images, and the main biological, physical, and socioeconomic components, we developed an environmental characterization of the zone. According with the natural features of the zone, including the watershed characteristics, the ecological resources potential, and the soil aptitude, we propose the optimal activities to be developed in each unity. A map of land use containing all the identified unites and the activities proposed to be developed is presented. According to our results, biodiversity conservation and productive activities in this coastal zone are totally compatible.