Forest pathology and entomology have been researched at Fort Valley Experimental Forest throughout its history. The pathogens and insects of particular interest are mistletoes, decay and canker fungi, rusts, bark beetles, and various defoliators. Studies on life history, biotic interactions, impacts, and control have been published and incorporated into silvicultural programs. A brief review of select pathogens and insects illustrates the evolution of research problems, approaches, and applications. Southwestern dwarf mistletoe, a serious pathogen of ponderosa pine, provides a case history of research transitioning from eradication methods for a menacing pest to adaptive management for an ecological keystone species.