The Science Framework is intended to link the Department of the Interior’s Integrated Rangeland Fire Management Strategy with long-term strategic conservation and restoration actions in the sagebrush biome. The focus is on sagebrush (Artemisia spp.) ecosystems and sagebrush dependent species with an emphasis on Greater sage-grouse (Centrocercus urophasianus). Part 1 of the Science Framework, published in 2017, provides the scientific information and decision-support tools for prioritizing areas for management and determining effective management strategies across the sagebrush biome. Part 2, this document, provides the management considerations for applying the information and tools in Part 1. Part 2 is intended to facilitate implementation of resource management priorities and use of management strategies that increase ecosystem resilience to disturbance and resistance to nonnative invasive annual grasses. The target audience of Part 2 is field managers, resource specialists, and regional and national-level managers. The topics addressed in this volume include adaptive management and monitoring, climate adaptation, wildfire and vegetation management, nonnative invasive plant management, application of National Seed Strategy concepts, livestock grazing management, wild horse and burro considerations, and integration and tradeoffs. Geospatial data, maps, and models for the Science Framework are provided through the U.S. Geological Survey’s ScienceBase database and Bureau of Land Management’s Landscape Approach Data Portal. The Science Framework is intended to be adaptive and will be updated as additional data become available on other values and species at risk. It is anticipated that the Science Framework will be widely used to: (1) inform emerging strategies to conserve sagebrush ecosystems, sagebrush dependent species, and human uses of the sagebrush system; and (2) assist managers in prioritizing and planning on-the-ground restoration and mitigation actions across the sagebrush biome.