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    Author(s): Kimberly C. Smith; Jacqueline L. Robertson
    Date: 1984
    Source: Gen. Tech. Rep. PSW-78. Berkeley, Calif.: U.S. Department of Agriculture, Forest Service, Pacific Southwest Forest and Range Exp. Stn. 12 p
    Publication Series: General Technical Report (GTR)
    Station: Pacific Southwest Research Station
    PDF: Download Publication  (500 KB)

    Description

    Careful selection of an experimental design for a bioassay substantially improves the precision of effective dose (ED) estimates. Design considerations typically include determination of sample size, dose selection, and allocation of subjects to doses. DOSESCREEN is a computer program written to help investigators select an efficient design for the estimation of an arbitrary ED. This report establishes the statistical basis for DOSESCREEN and suggests several ways to utilize DOSESCREEN out-put. A copy of the computer program in Fortran 77 is provided so users can easily convert DOSESCREEN to their own computer system.

    Publication Notes

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    • This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.

    Citation

    Smith, Kimberly C.; Robertson, Jacqueline L. 1984. DOSESCREEN: a computer program to aid dose placement. Gen. Tech. Rep. PSW-GTR-78. Berkeley, CA: U.S. Department of Agriculture, Forest Service, Pacific Southwest Forest and Range Experiment Station. 12 p.

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    Keywords

    bioassay, experimental design, effective doses

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