Skip to Main Content
U.S. Forest Service
Caring for the land and serving people

United States Department of Agriculture

Home > Search > Publication Information

  1. Share via EmailShare on FacebookShare on LinkedInShare on Twitter
    Dislike this pubLike this pub
    Author(s): Thomas W. Jeffries; Igor V. Grigroriev; Jane Grimwood; Jose M. Laplaza; Andrea Aerts; Asaf Salamov; Jeremy Schmutz; Erika Lindquist; Paramvir Dehal; Harris Shapiro; Yong-Su Jin; Volkmar Passoth; Paul M. Richardson
    Date: 2007
    Source: Nature biotechnology. Vol. 25, no. 3 (Mar. 2007): Pages 319-326.
    Publication Series: Miscellaneous Publication
    PDF: View PDF  (378 KB)

    Description

    Xylose is a major constituent of plant lignocellulose, and its fermentation is important for the bioconversion of plant biomass to fuels and chemicals. Pichia stipitis is a well-studied, native xylose-fermenting yeast. The mechanism and regulation of xylose metabolism in P. stipitis have been characterized and genes from P. stipitis have been used to engineer xylose metabolism in Saccharomyces cerevisiae. We have sequenced and assembled the complete genome of P. stipitis. The sequence data have revealed unusual aspects of genome organization, numerous genes for bioconversion, a preliminary insight into regulation of central metabolic pathways and several examples of colocalized genes with related functions. The genome sequence provides insight into how P. stipitis regulates its redox balance while very efficiently fermenting xylose under microaerobic conditions.

    Publication Notes

    • We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
    • This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.

    Citation

    Jeffries, Thomas W.; Grigroriev, Igor V.; Grimwood, Jane; Laplaza, Jose M.; Aerts, Andrea; Salamov, Asaf; Schmutz, Jeremy; Lindquist, Erika; Dehal, Paramvir; Shapiro, Harris; Jin, Yong-Su; Passoth, Volkmar; Richardson, Paul M. 2007. Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis. Nature biotechnology. Vol. 25, no. 3 (Mar. 2007): Pages 319-326.

    Keywords

    Wood, biodegradation, nucleotide sequence, genomes, alcohol, genetic engineering, microbial metabolism, yeast fungi, biotechnology, fermentation, yeast, genetics, fungi, industrial applications, wood decaying fungi, lignocellulose, ethanol, xylose, Pichia stipitis, decay fungi

    Related Search


    XML: View XML
Show More
Show Fewer
Jump to Top of Page