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    Author(s): Kelli Hoover; Merideth A. Humphries; Alyssa R. Genfron; James M. Slavicek
    Date: 2010
    Source: Journal of Invertebrate Pathology. 104: 150-152.
    Publication Series: Scientific Journal (JRNL)
    Station: Northern Research Station
    PDF: View PDF  (244.07 KB)

    Description

    Enhancins are metalloproteases found in many betabaculoviruses and several alphabaculoviruses, which enhance alphabaculovirus potency by degrading a protein component of the peritrophic matrix (PM), facilitating passage of virions through this structure. Earlier studies on betabaculovirus enhancins within heterologous systems suggested that enhancins facilitate virion binding to midgut cells. We compared the potency of wild-type Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV) with that of single and double enhancin deletion viruses in L. dispar in the presence and absence of an intact PM. Compared to wild-type virus, the double enhancin deletion virus was 6-fold and 14-fold less potent, respectively, indicating that within this homologous system the LdMNPV enhancin genes have a function beyond PM degradation.

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    Citation

    Hoover, Kelli; Humphries, Merideth A.; Genfron, Alyssa R.; Slavicek, James M. 2010. Impact of viral enhancin genes on potency of Lymantria dispar multiple nucleopolyhedrovirus in L dispar following disruption of the peritrophic matrix. Journal of Invertebrate Pathology. 104: 150-152.

    Keywords

    Lymantria dispar, Lymantria dispar nucleopolyhedrovirus, enhancin, viral potency, gypsy moth, peritrophic matrix

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