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Sequence and analysis of the genome of a baculovirus pathogenic for Lymantria disparAuthor(s): John Kuzio; Margot N. Pearson; Steve H. Harwood; C. Joel Funk; Jay T. Evans; James M. Slavicek; George F. Rohrmann
Source: Virology. 253: 17-34.
Publication Series: Scientific Journal (JRNL)
Station: Northeastern Research Station
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DescriptionThe genome of the Lymantria dispar multinucleocapsid nucleopolyhedrovirus (LdMNPV) was sequenced and analyzed. It is composed of 161,046 bases with a G + C content of 57.5% and contains 163 putative open reading frames (ORFs) of ≥150 nucleotides. Homologs were found to 95 of the 155 genes predicted for the Autographa californica MNPV (AcMNPV) genome. More than 9% of the LdMNPV genome was occupied by 16 repeated genes related to AcMNPV ORF2. Readily identifiable homologs of several genes that have been reported to play important roles in the AcMNPV life cycle are not present; these include ie-2, a transcriptional transactivator, and gp64, a major envelope glycoprotein of the nonoccluded form of the virus. A number of genes lacking in AcMNPV but present in other baculoviruses were identified; these include two viral enhancing factor homologs, a second copy of a conotoxin-like gene, and a dutpase homolog.
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CitationKuzio, John; Pearson, Margot N.; Harwood, Steve H.; Funk, C. Joel; Evans, Jay T.; Slavicek, James M.; Rohrmann, George F. 1999. Sequence and analysis of the genome of a baculovirus pathogenic for Lymantria dispar. Virology. 253: 17-34.
Keywordsbaculovirus, nuclear polyhedrosis virus, genome sequence
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