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    Author(s): Rita Stanikunaite; Shabana I. Khan; James M. Trappe; Samir A. Ross
    Date: 2009
    Source: Phytotherapy Research. 23: 575-578
    Publication Series: Scientific Journal (JRNL)
    Station: Pacific Northwest Research Station
    PDF: View PDF  (1.02 MB)

    Description

    The ethanol extract of fruiting bodies of Elaphomyces granulatus, a truffle-like fungus, was evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory and antioxidant activities. Inhibition of COX-2 activity was evaluated in mouse macrophages (RAW 264.7). The extract of E. granulatus caused a 68% inhibition of COX-2 activity at 50 ug/mL. Bioassay-guided investigation led to the isolation and identification of two active compounds, syringaldehyde and syringic acid.

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    Citation

    Stanikunaite, Rita; Khan, Shabana I.; Trappe, James M.; Ross, Samir A. 2009. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytotherapy Research. 23: 575-578.

    Keywords

    Elaphomyces granulatus, Ascomycota, hypogeous, truffle, COX-2, RAW 264.7 cells, antiinflammatory, antioxidants, DCFH oxidation, HL-60 cells

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