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Integration of Chemical and Biological Catalysis: Production of Furylglycolic Acid from Glucose via CortalceroneAuthor(s): Thomas J. Schwartz; Samuel M. Goodman; Christian M. Osmundsen; Esben Taarning; Michael D. Mozuch; Jill Gaskell; Daniel Cullen; Philip J. Kersten; James A. Dumesic
Source: ACS Catal. Volume 3, 2013; pp. 2689-2693.
Publication Series: Scientific Journal (JRNL)
Station: Forest Products Laboratory
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DescriptionFurylglycolic acid (FA), a pseudoaromatic hydroxy-acid suitable for copolymerization with lactic acid, can be produced from glucose via enzymatically derived cortalcerone using a combination of Brønsted and Lewis acid catalysts. Cortalcerone is first converted to furylglyoxal hydrate (FH) over a Brønsted acid site (HCl or Al-containing betazeolite), and FH is subsequently converted to FA over a Lewis acid site (Sn-beta zeolite). Selectivity for conversion of FH to FA is as high as 80% at 12% conversion using tetrahydrofuran (THF) as a solvent at 358 K. Higher conversion of FH leads to FA-catalyzed degradation of FH and subsequent deactivation of the catalyst by the deposition of carbonaceous residues. The deactivated catalyst can be regenerated by calcination. Cortalcerone can be produced from 10% glucose solution using recombinant Escherichia coli strains expressing pyranose 2-oxidase and aldos-2-ulose dehydratase from the wood-decay fungus Phanerochaete chrysosporium BKM-F-1767. This enzymatically derived cortalcerone is converted in one pot to FA in a methanol/water solvent over an Al-containing Sn-beta zeolite possessing both Brønsted and Lewis acid sites, achieving 42% selectivity to FA at 53% cortalcerone conversion.
CitationSchwartz, Thomas J.; Goodman, Samuel M.; Osmundsen, Christian M.; Taarning, Esben; Mozuch, Michael D.; Gaskell, Jill; Cullen, Daniel; Kersten, Philip J.; Dumesic, James A. 2013. Integration of Chemical and Biological Catalysis: Production of Furylglycolic Acid from Glucose via Cortalcerone. ACS Catal. Volume 3, 2013; pp. 2689-2693.
KeywordsSn-beta zeolite, MPVO reaction, hydride transfer, poly(lactic acid), whole-cell enzyme catalysis, pyranose-2-oxidase
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