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Copper radical oxidases and related extracellular oxidoreductases of wood-decay AgaricomycetesAuthor(s): Phil Kersten; Dan Cullen
Source: Fungal Genetics and Biology, Volume 72, 2014; pp. 124-130.
Publication Series: Scientific Journal (JRNL)
Station: Forest Products Laboratory
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DescriptionExtracellular peroxide generation, a key component of oxidative lignocellulose degradation, has been attributed to various enzymes including the copper radical oxidases. Encoded by a family of structurally related sequences, the genes are widely distributed among wood decay fungi including three recently completed polypore genomes. In all cases, core catalytic residues are conserved, but five subfamilies are recognized. Glyoxal oxidase, the most intensively studied representative, has been shown physiologically connected to lignin peroxidase. Relatively little is known about structure–function relationships among more recently discovered copper radical oxidases. Nevertheless, differences in substrate preferences have been observed in one case and the proteins have been detected in filtrates of various wood-grown cultures. Such diversity may reflect adaptations to host cell wall composition and changing environmental conditions.
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CitationKersten, Phil; Cullen, Dan. 2014. Copper radical oxidases and related extracellular oxidoreductases of wood-decay Agaricomycetes. Fungal Genetics and Biology, Volume 72, 2014; pp. 124-130.
KeywordsGlyoxal oxidase, Lignin, White rot, Brown rot, Lignin peroxidase
- A novel extracellular multicopper oxidase from Phanerochaete chrysosporium with ferroxidase activity
- Structure, organization, and transcriptional regulation of a family of copper radical oxidase genes in the lignin-degrading basidiomycete Phanerochaete chrysosporium
- A comparative genomic analysis of the oxidative enzymes potentially involved in lignin degradation by Agaricus bisporus
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