Skip to Main Content
Grand challenges in evolutionary and population genetics: The importance of integrating epigenetics, genomics, modeling, and experimentationAuthor(s): Samuel A. Cushman
Source: Frontiers in Genetics. 5: Article 197.
Publication Series: Scientific Journal (JRNL)
Station: Rocky Mountain Research Station
View PDF (414.04 KB)
DescriptionThis is a time of explosive growth in the fields of evolutionary and population genetics, with whole genome sequencing and bioinformatics driving a transformative paradigm shift (Morozova and Marra, 2008). At the same time, advances in epigenetics are thoroughly transforming our understanding of evolutionary processes and their implications for populations, species and communities (Callinan and Feinberg, 2006). These revolutionary changes present tremendous opportunities and challenges to our field (Table 1). In this essay, I will lay out my personal interpretation of what some of the biggest opportunities and challenges are for evolutionary and population genetics over the next decade. I believe that for our field to take full advantage of these tremendous opportunities, we must effectively combine genomics, epigenetics, bioinformatics, experiments and modeling (Figure 1). Genomic pipelines are rapidly producing intractably large volumes of data (e.g., Griffiths-Jones et al., 2008), often without sufficient forethought about what the data will be used for, or how it will be curated, archived, and analyzed. We would be well served by thinking carefully in advance about hypotheses, what data would be best suited to address them, what experiments could be designed to evaluate and validate results, and how powerful modeling approaches could be coupled with experimentation and data mining to generalize experimental results and explore their implications across scales of biological organization from nucleotides to ecosystems.
- You may send email to firstname.lastname@example.org to request a hard copy of this publication.
- (Please specify exactly which publication you are requesting and your mailing address.)
- We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
- This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.
CitationCushman, Samuel A. 2014. Grand challenges in evolutionary and population genetics: The importance of integrating epigenetics, genomics, modeling, and experimentation. Frontiers in Genetics. 5: Article 197.
Keywordsevolutionary and population genetics, epigenetics, bioinformatics, genomics, modeling
- Current status, future opportunities, and remaining challenges in landscape genetics [Chapter 14]
- Biotechnology in the southern research station: a problem analysis
- The genetic architecture of local adaptation and the genomic exploration of rugged evolutionary landscapes within species of Pinus subgenus Strobus
XML: View XML