Skip to Main Content
Correlates of virulence in a frog-killing fungal pathogen: evidence from a California amphibian declineAuthor(s): Jonah Piovia-Scott; Karen Pope; S. Joy Worth; Erica Bree Rosenblum; Dean Simon; Gordon Warburton; Louise A. Rollins-Smith; Laura K. Reinert; Heather L. Wells; Dan Rejmanek; Sharon Lawler; Janet Foley
Source: The ISME Journal. 9(7): 1570-1578
Publication Series: Scientific Journal (JRNL)
Station: Pacific Southwest Research Station
Download Publication (612.98 KB)
DescriptionThe fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused declines and extinctions in amphibians worldwide, and there is increasing evidence that some strains of this pathogen are more virulent than others. While a number of putative virulence factors have been identified, few studies link these factors to specific epizootic events. We documented a dramatic decline in juvenile frogs in a Bd-infected population of Cascades frogs (Rana cascadae) in the mountains of northern California and used a laboratory experiment to show that Bd isolated in the midst of this decline induced higher mortality than Bd isolated from a more stable population of the same species of frog. This highly virulent Bd isolate was more toxic to immune cells and attained higher density in liquid culture than comparable isolates. Genomic analyses revealed that this isolate is nested within the global panzootic lineage and exhibited unusual genomic patterns, including increased copy numbers of many chromosomal segments. This study integrates data from multiple sources to suggest specific phenotypic and genomic characteristics of the pathogen that may be linked to disease-related declines.
- You may send email to email@example.com to request a hard copy of this publication.
- (Please specify exactly which publication you are requesting and your mailing address.)
- We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
- This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.
CitationPiovia-Scott, Jonah; Pope, Karen; Joy Worth, S.; Rosenblum, Erica Bree; Poorten, Thomas; Refsnider, Jeanine; Rollins-Smith, Louise A.; Reinert, Laura K.; Wells, Heather L.; Rejmanek, Dan; Lawler, Sharon; Foley, Janet. 2015. Correlates of virulence in a frog-killing fungal pathogen: evidence from a California amphibian decline. The ISME Journal. 9(7): 1570-1578.
- Itraconazole treatment reduces Batrachochytrium dendrobatidis prevalence and increases overwinter field survival in juvenile Cascades frogs
- Factors related to the distribution and prevalence of the fungal pathogen Batrachochytrium dentrobatidis in Rana cascadae and other amphibians in the Klamath Mountains
- Distribution and pathogenicity of Batrachochytrium dendrobatidis in boreal toads from the Grand Teton area of western Wyoming
XML: View XML