In the Northeastern U.S., drought is expected to increase in frequency over the next century, and therefore, the responses of trees to drought are important to understand. There is recent debate about whether land-use change or moisture availability is the primary driver of changes in forest species composition in this region. Some argue that fire suppression from the early twentieth century to present has resulted in an increase in shade-tolerant and pyrophobic tree species that are drought intolerant, while others suggest precipitation variability as a major driver of species composition. From this debate, an emerging hypothesis is that mesophication and increases in the abundance of mesophytic genera (e.g., Acer, Betula, and Fagus) resulted in forests that are more vulnerable to drought. This review examines the published literature and factors that contribute to drought vulnerability of Northeastern U.S. forests. We assessed two key concepts related to drought vulnerability, including drought tolerance (ability to survive drought) and sensitivity (short-term responses to drought), with a focus on Northeastern U.S. species. We assessed drought-tolerance classifications for species, which revealed both consistencies and inconsistencies, as well as contradictions when compared to actual observations, such as higher mortality for drought-tolerant species. Related to drought sensitivity, recent work has focused on isohydric/ anisohydric regulation of leaf water potential. However, based on the review of the literature, we conclude that drought sensitivity should be viewed in terms of multiple variables, including leaf abscission, stomatal sensitivity, turgor pressure, and dynamics of non-structural carbohydrates. Genera considered drought sensitive (e.g., Acer, Betula, and Liriodendron) may actually be less prone to drought-induced mortality and dieback than previously considered because stomatal regulation and leaf abscission in these species are effective at preventing water potential from reaching critical thresholds during extreme drought. Independent of drought-tolerance classification, trees are prone to dieback and mortality when additional stressors are involved such as insect defoliation, calcium and magnesium deficiency, nitrogen saturation, and freeze-thaw events. Overall, our literature review shows that multiple traits associated with drought sensitivity and tolerance are important as species may rely on different mechanisms to prevent hydraulic failure and depleted carbon reserves that may lead to mortality.