Skip to Main Content
genome-wide association and metabolic pathway analysis of corn earworm resistance in maizeAuthor(s): Marilyn L. Warburton; Erika D. Womack; Juliet D. Tang; Adam Thrash; J. Spencer Smith; Wenwei Xu; Seth C. Murray; W. Paul Williams
Source: The Plant Genome. 11(1): 1-8.
Publication Series: Scientific Journal (JRNL)
Station: Forest Products Laboratory
Download Publication (580.0 KB)
DescriptionMaize (Zea mays mays L.) is a staple crop of economic, industrial, and food security importance. Damage to the growing ears by corn earworm [Helicoverpa zea (Boddie)] is a major economic burden and increases secondary fungal infections and mycotoxin levels. To identify biochemical pathways associated with native resistance mechanisms, a genome-wide association analysis was performed, followed by pathway analysis using a gene-set enrichment-based approach. The gene-set enrichment exposed the cumulative effects of genes in pathways to identify those that contributed the most to resistance. Single nucleotide polymorphism–trait associations were linked to genes including transcription factors, protein kinases, hormone-responsive proteins, hydrolases, pectinases, xylogluconases, and the flavonol synthase gene (in the maysin biosynthesis pathway). The most significantly associated metabolic pathways identified included those that modified cell wall components, especially homogalacturonan, wax esters, and fatty acids; those involved in antibiosis, especially 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), flavonoids, and phenolics; and those involved in plant growth, including N uptake and energy production. The pathways identified in this study, and especially the cell wall-associated pathways, identified here for the first time, provide clues to resistance mechanisms that could guide the identification of new resistant ideotypes and candidate genes for creation of resistant maize germplasm via selection of natural variants or gene editing.
- We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
- This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.
CitationWarburton, Marilyn L.; Womack, Erika D.; Tang, Juliet D.; Thrash, Adam; Smith, J. Spencer; Xu, Wenwei; Murray, Seth C.; Williams, W. Paul. 2018. Genome-wide association and metabolic pathway analysis of corn earworm resistance in Maize. The Plant Genome. 11(1): 1-8.
KeywordsGenome-wide association, metabolic pathway analysis, host plant resistance, maize, corn earworm
- Sustainability of corn stover harvest strategies in Pennsylvania
- Response surface methodology (RSM) to evaluate moisture effects on corn stover in recovering xylose by DEO hydrolysis
- Leveraging GWAS data to identify metabolic pathways and networks involved in maize lipid biosynthesis
XML: View XML