Skip to Main Content
Application of electronic-nose technologies and VOC-biomarkers for the noninvasive early diagnosis of gastrointestinal diseasesAuthor(s): Alphus D. Wilson
Publication Series: Scientific Journal (JRNL)
Station: Southern Research Station
View PDF (1.0 MB)
DescriptionConventional methods utilized for clinical diagnosis of gastrointestinal (GI) diseases have employed invasive medical procedures that cause stress, anxiety and pain to patients. These methods are often expensive, time-consuming, and require sophisticated chemical-analysis instruments and advanced modeling procedures to achieve diagnostic interpretations. This paper reviews recent applications of simpler, electronic-nose (e-nose) devices for the noninvasive early diagnosis of a wide range of GI diseases by collective analysis of headspace volatile organic compound (VOC)-metabolites from clinical samples to produce disease-specific aroma signatures (VOC profiles). A different “metabolomics” approach to GI disease diagnostics, involving identifications and quantifications of disease VOC-metabolites, are compared to the electronic-nose approach based on diagnostic costs, accuracy, advantages and disadvantages. The importance of changes in gut microbiome composition that result from disease are discussed relative to effects on disease detection. A new diagnostic approach, which combines the use of e-nose instruments for early rapid prophylactic disease-screenings with targeted identification of known disease biomarkers, is proposed to yield cheaper, quicker and more dependable diagnostic results. Some priority future research needs and coordination for bringing e-nose instruments into routine clinical practice are summarized
- You may send email to firstname.lastname@example.org to request a hard copy of this publication.
- (Please specify exactly which publication you are requesting and your mailing address.)
- We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
- This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.
CitationWilson, A.D. 2018. Application of electronic-nose technologies and VOC-biomarkers for the noninvasive early diagnosis of gastrointestinal diseases. Sensors. 18(8): 2613.
Keywordsbacterial dysbiosis, early noninvasive diagnoses, electronic aroma detection, e-nose devices, GI-disease biomarkers, healthcare applications, metabolite profiles, point-of-care testing, volatile organic compounds
- Recent applications of electronic-nose technologies for the noninvasive early diagnosis of gastrointestinal diseases
- Applications of electronic-nose technologies for noninvasive early detection of plant, animal and human diseases
- Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath
XML: View XML