These proceedings contain the full-length papers, extended abstracts, and short-form abstracts of oral presentations and posters given at the Seventh Interagency Conference on Research in the Watersheds (7th ICRW)—Enhancing Landscapes for Sustainable Intensification and Watershed Resiliency, jointly hosted by the U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), and the University of Georgia, Tifton, GA, and held virtually November 16–19, 2020. The 7th ICRW focused on the science and management of increased human and natural drivers of watershed change throughout the United States. The conference was structured to present and address key scientific and management issues faced by watershed managers and scientists throughout the U.S. Research was presented by Federal, State, and local scientists, academics, and non-governmental organizations focusing on managing complex watershed systems and watershed components (e.g., streams, rivers, lakes, estuaries, etc.). Thematic areas included watershed modeling, responses to climate change, management strategies, integration of science and management, water quality and quantity, long-term agroecosystem science, as well as ecosystem-specific themes such as coastal plain watersheds and wetlands. The conference was hosted by the USDA-ARS and the University of Georgia, with material and in-kind support from the following organizations: Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI), the USDA Forest Service, the U.S. Geological Survey, the U.S. Bureau of Land Management, the U.S. Fish and Wildlife Service, the U.S. Environmental Protection Agency, NASA, and the U.S. Department of Energy. The 7th ICRW was built on the foundation laid by the previous hosting organizations: USDA Agricultural Research Service (2003), USDA Forest Service (2006 and 2015), U.S. Geological Survey and CUAHSI (2009), the Bureau of Land Management and National Park Service (2011), and U.S. Environmental Protection Agency (2018). The 8th ICRW will be hosted by the U.S. Geological Survey in Corvallis, Oregon. The conference is planned for June 2023.